Author: mobilegrow

College students often drink alcohol and use drugs simultaneously during parties and other social events

The portal content is flexible to allow for real-time tailoring to prevent/reduce misuse, addressing heterogeneity in motives and other risk factors . Use of the fully-crossed 4-group RCT design will help identify the optimal combination of interventions based on risk severity in terms of efficacy, cost-effectiveness, and reimbursement mechanisms. Our conceptual model, which guides the examination […]

The modulation of LPS-regulated gene expression by CBD was more pronounced as compared with THC

Interestingly, the mechanisms that give rise to either the protective or the damaging microglial phenotypes are not fully elucidated. Enhancing the microglial-mediated innate immunity in the CNS and/or preventing the harmful effects associated with their chronic activation may offer new therapeutic approaches for the treatment of brain injury and neurodegenerative diseases. One of the most […]

The BSI-18 T-scores calculated in this study had high internal consistency

Informed consent was obtained before starting the behavioral survey, which was administered via hand-held tablet computers. All study procedures were approved by the Institutional Review Board at the University of California, San Francisco. Written consent was obtained from all youths aged 18 years or older and written assent was given by younger participants . Psychosocial […]

We dichotomized the severity of substance use as low versus moderate to high risk

Regardless, our analyses demonstrate some measure of construct validity in that higher scores on both measures were linked to reporting mental health conditions in our study. Our measure of sexual orientation “outness” was only asked for gay-identified participants, and a general measure should be included in future studies. A nurse-administered structured interview was used to […]

Studies applying CHR criteria to date have focused primarily on psychosis spectrum outcomes

VCAM-1 and ICAM-1 are released in response to inflammation and facilitate the adhesion and migration of immune and viral factors into and across the vascular endothelium . While VCAM-1 is exclusively expressed on endothelial cells, ICAM-1 is also expressed on leukocytes, astrocytes, and microglial cells . uPAR is a glycoprotein expressed on endothelial cells, in addition […]

Our study demonstrated that HIV self-testing can reach individuals at high risk

Risk behavior, attitudes toward HIV testing and treatment, perception of HIV-related stigma, and medical mistrust were not associated with ordering a self-test kit. Finally, we recorded high prevalence of alcohol and cannabis use among participants. Overall, information search sites performed poorly in recruiting and enrolling individuals. The site advertisement metrics showed a better click-through rate […]

The SCID was used to rule out psychosis and to identify DSM-IV Axis I or cluster A disorders

HCV-infected women were older than HIV-monoinfected women, and both groups were older than women with neither infection. More than half of all women were African American, with the largest proportion among the HCV-infected group. Compared with HIV-infected women and those with neither infection, HCV-infected women were more likely to report being in menopause, having a […]

AEA also blocks the standing-outward K+ current IKso and induces depolarization in cerebellar granule neurons

The changes in A-type potassium channel gating caused by 2-AG include a shift of the voltage-dependent activation of IA in the depolarizing direction, acceleration of the inactivation kinetics, and reduction of the maximal current for large depolarizations. The IA–inhibiting effect of 2-AG likely results from a direct action on the channel through a membrane lipid […]

Subjective memory complaints were also associated with worse verbal memory

One debate in the HIV literature is the extent to which HIV disease is associated with accelerated aging as opposed to other comorbid conditions or other lifestyle factors associated with HIV. However, it is difficult to differentiate the effect of HIV itself versus the downstream effects of HIV or lifestyle factors associated with risk of contracting […]