Author: mobilegrow

The MACH 14 cohort is a dataset pooled from 16 studies conducted at 14 sites across 12 states. Each study in MACH14 used electronic data monitoring pillcaps to objectively measure participants’ adherence to antiretroviral medication. The focus of this study was on non-methadone substance abuse treatment so studies conducted in methadone maintenance programs were not considered in […]

The sinuses, a connected system of hollow cavities in the skull lined with mucosa tissue that has a thin layer of mucus, may help humidify air in the nasal cavity. In 2015, a $15-million grant by the National Science Foundation kicked off further research into how animals, including humans, locate the source of an odor, […]

The BART scores increased significantly with abstinence , whereas the IGT scores did not change during abstinence. Self-reported total and motor impulsivity decreased significantly with abstinence and the non-planning score tended to decrease . The following changes were observed when restricting our longitudinal analysis to only those 17 PSU with baseline and follow-up data: general intelligence, executive […]

DSI can be blocked by postsynaptic Ca2 buffers or initiated by activity restricted to the postsynaptic side, and likely involves the opening of voltage-gated Ca2 channels , or release from intracellular stores. Changes in postsynaptic GABAA receptor sensitivity have been excluded, since the response to iontophoretically applied GABA did not change, and DSI had no effect on […]

This clear morphological finding is also supported by work with CB_x0005_ /_x0005_ mice, which suggests that an additional receptor, pharmacologically related, but molecularly distinct from the CB1, may mediate the cannabinoid modulation of glutamatergic transmission in the hippocampus . We will return to this hypothesis in section IVB1B.CB1 receptors are also present in several subcortical nuclei […]

First, motivated by the potential therapeutic applications of cannabis-like molecules, laboratories in academia and the pharmaceutical industry began to develop families of synthetic analogs of delta-9-THC. These agents exerted pharmacological effects that were qualitatively similar to those of delta-9- THC but displayed both greater potency and stereoselectivity. The latter feature cannot be reconciled with nonspecific membrane interactions, […]

Chronic inflammation and immune activation potentially predispose PLWH to greater risk for premature and accentuated aging, making prevention and treatment of comorbidities an important component of HIV-related care . Specifically, the three most common comorbidities for PLWH are hypertension, hyperlipidemia, and endocrine disease , which are all components of metabolic syndrome . MetS is conceptualized as […]

Vaping is a term relating to heating a liquid and inhaling the “vapor” produced. Vaping first became popular as a means of inhaling tobacco without combusting it. Electronic cigarettes consisting of a battery, heating coil, and liquid reservoir usually containing nicotine were developed and went through several “generations” of modification. The third generation consists normally of a vape […]

Such risk assessment approaches can and have been applied to environmental odors. Unlike risk assessment of toxic chemicals, odor studies can include human panels. Risk assessment is directly applicable to the investigation of health risks from odors .The objective of this thesis is to conduct a critical literature evaluation, supplemented with interviews of odor experts […]

The identified increase in variance explained by PTSD emphasizes that PTSD is a significant predictor of later addiction severity among individuals who face early substance use problems. These results are consistent with previous research, which associated early childhood experience of trauma with early substance use onset and transition to poly drug use . Additionally, previous handful […]