A major strength of this study was its large international multicentre prospective cohort with excellent follow-up and complete data available for this analysis. Women were recruited from a clearly defined population of nulliparous women, with meticulous data monitoring protocols to reduce data entry or transcription errors and ensure the quality of data. While there are […]
Author: mobilegrow
A recent review by Agrawal describes multiple etiologies that influence their comorbidity
Despite the high co-morbidity between marijuana and nicotine use, only few studies have directly addressed the mechanisms that lead to their concurrent use. This includes route of administration,cross drug adaptation, response to treatments, environmental effects and genetic factors.Others have also alluded to the “gateway drug” hypothesis whereby the use of one drug may potentiate the effects […]
An infectious workup was negative and a CT angiogram ruled out pulmonary embolism
Low CD4 T cell count was the dominant predictor of infectious pulmonary diagnoses in multi-variable analyses, yet the association between marijuana smoking and infectious pulmonary diagnoses remained significant in adjusted analyses restricted to visits with CD4 ≥ 200 cells/μl, and sensitivity analyses with no CD4 restriction. Tobacco smoking, reported during follow-up for 44% of HIV+ […]
There are several mechanisms through which marijuana use might affect degree completion
The coding categories used in this study may raise questions about the results in terms of validity and reliability. Thus, future studies should test the same categories that this study used and then develop more correct coding categories. Lastly, the time period for this study was between 1995 and 2014. Although marijuana was initially legalized […]
We hypothesize that the combined effects of marijuana and alcohol will be protective for patients with TBI
Alcohol intoxication is a common comorbidity in traumatic brain injury,with 30%–50% of all TBIs occurring under the influence of alcohol. Preclinical studies have indicated that ethanol pretreatment results in a faster recovery with better outcomes after TBI. However, numerous clinical studies have examined the relationship of alcohol exposure and risk of mortality in patients with TBI […]
Respective confidence intervals thus only consider between-country variation of point estimates and should thus be interpreted cautiously
In some countries, such as Spain, only cannabinoid-based preparations are approved for select diseases , while other countries, such as Germany or UK, have established a more liberal approach, which allows physicians to prescribe unprocessed herbal cannabis for certain illnesses. Based on a growing body of evidence supporting the therapeutic potential of cannabis, the World Health […]
Detailed genetic atlas would facilitate the designing and further breeding of cannabis varieties for preferred metabolic yields
For cannabinoid biosynthesis, there exist three major reactions: biosynthesis of monoterpene precursor via MEP and fatty acid intermediate from polyketide pathway, prenylation of the precursors, and cyclization. The MEP pathway in plastid prenylation is localized in the chloroplast membrane, where the C-prenylated CBGA synthase is membrane-bound. The integration of the enzyme in the membrane seems essential, and the folding pattern […]
Whether chronic cannabis use affects CNS function through dysbiosis of oral micro-biome remains unknown
Oral bacteria can enter into the systemic circulation through inflamed gingiva and thereby affect peripheral organs and the CNS. In mice, oral administration of Campylobacter jejuni activated visceral sensory nuclei in the brainstem that processed gastro-intestinal sensory information; Porphyromonas gingivalis, an oral pathogen contributing to the development of chronic periodontitis, may be a risk factor […]
There are also other individual sites with Cannabis/Humulus pollen that need more bibliographic research
Similarly, the former continental-scale meta-analysis of fossil pollen and archeological evidence indicates that the IP was among the last European areas – along with the British Isles and the Scandinavian region – where Cannabis was cultivated, and this occurred during the Roman Empire and the Early Middle Ages . However, these continental-wide analyses include only […]
Cannabis and tobacco smoking also pose additive risk for toxicant exposure and psychotic symptoms
A placebo-controlled crossover study involving individuals with infrequent use given cannabis ‘edibles’ at different doses found dose-dependent acute impairments in attention, memory and psychomotor performance. Perceptible drug effect onset occurred 30-60 minutes after intake, peaked at 2-5 hours, and lasted eight hours or more . While the cognitive impairments observed were comparable to similar doses of inhaled cannabis […]