Like tobacco smoke, marijuana smoke has been associated with numerous adverse pulmonary effects in humans including airway inflammation, chronic bronchitis, edema, mucus hypersecretion, and the impairment of large airway function and lung efficiency.Moreover, Aldington et al. showed that the impairment of large airway function and lung efficiency is 2.5–5 times greater in marijuana smokers than […]
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The application of MRS to the study of chronic marijuana users is limited in the current literature
The results and conclusions from this study should be examined within the context of its limitations. First, the data-set examined in this analysis was derived from two larger parent projects,thus, certain variables of interest could not be manipulated or controlled to study more detailed MJ-related effects.In spite of these limitations, MJ users were homogenous in their […]
Results from our study emphasise the need for tailored interventions for youth from lower SES households
A major strength of this study was its large international multicentre prospective cohort with excellent follow-up and complete data available for this analysis. Women were recruited from a clearly defined population of nulliparous women, with meticulous data monitoring protocols to reduce data entry or transcription errors and ensure the quality of data. While there are […]
A recent review by Agrawal describes multiple etiologies that influence their comorbidity
Despite the high co-morbidity between marijuana and nicotine use, only few studies have directly addressed the mechanisms that lead to their concurrent use. This includes route of administration,cross drug adaptation, response to treatments, environmental effects and genetic factors.Others have also alluded to the “gateway drug” hypothesis whereby the use of one drug may potentiate the effects […]
An infectious workup was negative and a CT angiogram ruled out pulmonary embolism
Low CD4 T cell count was the dominant predictor of infectious pulmonary diagnoses in multi-variable analyses, yet the association between marijuana smoking and infectious pulmonary diagnoses remained significant in adjusted analyses restricted to visits with CD4 ≥ 200 cells/μl, and sensitivity analyses with no CD4 restriction. Tobacco smoking, reported during follow-up for 44% of HIV+ […]
There are several mechanisms through which marijuana use might affect degree completion
The coding categories used in this study may raise questions about the results in terms of validity and reliability. Thus, future studies should test the same categories that this study used and then develop more correct coding categories. Lastly, the time period for this study was between 1995 and 2014. Although marijuana was initially legalized […]
We hypothesize that the combined effects of marijuana and alcohol will be protective for patients with TBI
Alcohol intoxication is a common comorbidity in traumatic brain injury,with 30%–50% of all TBIs occurring under the influence of alcohol. Preclinical studies have indicated that ethanol pretreatment results in a faster recovery with better outcomes after TBI. However, numerous clinical studies have examined the relationship of alcohol exposure and risk of mortality in patients with TBI […]
Respective confidence intervals thus only consider between-country variation of point estimates and should thus be interpreted cautiously
In some countries, such as Spain, only cannabinoid-based preparations are approved for select diseases , while other countries, such as Germany or UK, have established a more liberal approach, which allows physicians to prescribe unprocessed herbal cannabis for certain illnesses. Based on a growing body of evidence supporting the therapeutic potential of cannabis, the World Health […]
Detailed genetic atlas would facilitate the designing and further breeding of cannabis varieties for preferred metabolic yields
For cannabinoid biosynthesis, there exist three major reactions: biosynthesis of monoterpene precursor via MEP and fatty acid intermediate from polyketide pathway, prenylation of the precursors, and cyclization. The MEP pathway in plastid prenylation is localized in the chloroplast membrane, where the C-prenylated CBGA synthase is membrane-bound. The integration of the enzyme in the membrane seems essential, and the folding pattern […]
Whether chronic cannabis use affects CNS function through dysbiosis of oral micro-biome remains unknown
Oral bacteria can enter into the systemic circulation through inflamed gingiva and thereby affect peripheral organs and the CNS. In mice, oral administration of Campylobacter jejuni activated visceral sensory nuclei in the brainstem that processed gastro-intestinal sensory information; Porphyromonas gingivalis, an oral pathogen contributing to the development of chronic periodontitis, may be a risk factor […]