Historically, molecular genetic research on AAB has been limited to the examination of a small number of candidate genes with purported biological relevance; only recently have researchers begun to conduct atheoretical genome-wide scans for this phenotype.13,15,16 In our genome-wide investigation, we found that autosomal SNPs accounted for ~ 25% of the variation in a dimensional […]
Tag: cannabis cultivation
Primary trial findings and full study procedures were previously published
These findings occur in the context of extreme poverty and account for simultaneous influences of previous recent violent victimization and amphetamine use. Given the consistency of the relationship between dissociation and physical violence over time, identifying individuals who have high levels of dissociation within a broader context of trauma-informed care for homeless and unstably housed […]
A final note about interpreting the study’s findings is warranted
A reverse pattern appeared for transgender adolescents of color, however, such that transgender Latinx, American Indian or Alaskan Native, Black, Native Hawaiian or Pacific Islander, and multiracial adolescents evidenced greater adjusted odds of more frequent vaping relative to transgender white adolescents. For adolescents unsure of their gender identity, patterns were less consistent. Whereas Latinx, Black, […]
Over time one would expect these factors to further contribute to the effectiveness of CBIs
Use of a theoretical framework helps to explain the mechanisms of change by informing the causal pathways between specific intervention components and behavioral outcomes. Understanding these mechanisms improves our understanding of how and why a particular intervention works. There has been little attention as to how theoretical frameworks have informed the development of CBIs focused […]
Quantitative PCR analysis confirmed N. brasiliensis expression of both of these predicted genes
We validated the bioinformatic predictions for N. brasiliensis by quantitative real-time PCR and mass spectrometry and showed that N. brasiliensis produces endocannabinoids at all life cycle stages. Taken together, these studies show for the first time the production of endocannabinoids by parasitic helminths and suggest that helminth infection-induced endocannabinoids functionally influence the host immune response and […]
The PATH Study is an ongoing household cohort study of tobacco use and health among US youth and adults
One SNP on chromosome 7 in the gene IMMPL2 reached genome-wide significance. Another gene IINHBA-AS1 on chromosome 7 achieved genome-wide significance when analyzed by KGG4 that relies on a composite association score including all SNPs in each known gene. The significance of these associations was not influenced by “p-hacking” statistical biases common in GWAS because […]
College students often drink alcohol and use drugs simultaneously during parties and other social events
The portal content is flexible to allow for real-time tailoring to prevent/reduce misuse, addressing heterogeneity in motives and other risk factors . Use of the fully-crossed 4-group RCT design will help identify the optimal combination of interventions based on risk severity in terms of efficacy, cost-effectiveness, and reimbursement mechanisms. Our conceptual model, which guides the examination […]
The modulation of LPS-regulated gene expression by CBD was more pronounced as compared with THC
Interestingly, the mechanisms that give rise to either the protective or the damaging microglial phenotypes are not fully elucidated. Enhancing the microglial-mediated innate immunity in the CNS and/or preventing the harmful effects associated with their chronic activation may offer new therapeutic approaches for the treatment of brain injury and neurodegenerative diseases. One of the most […]
The BSI-18 T-scores calculated in this study had high internal consistency
Informed consent was obtained before starting the behavioral survey, which was administered via hand-held tablet computers. All study procedures were approved by the Institutional Review Board at the University of California, San Francisco. Written consent was obtained from all youths aged 18 years or older and written assent was given by younger participants . Psychosocial […]
We dichotomized the severity of substance use as low versus moderate to high risk
Regardless, our analyses demonstrate some measure of construct validity in that higher scores on both measures were linked to reporting mental health conditions in our study. Our measure of sexual orientation “outness” was only asked for gay-identified participants, and a general measure should be included in future studies. A nurse-administered structured interview was used to […]