We accounted for the multiplicity of measures by correcting alpha levels via a modified Bonferroni procedure . This approach considers the mean correlation between variables and the number of tests in the adjustment of alpha levels. All alpha levels were adjusted for both traditional neurocognitive assessment and BIS-11 and their average inter-correlation coefficients in primary and secondary […]
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Raycasting from the eye position was initially used to enable object selection in the direction of gaze
The participants were free to move around and interact with various objects within the VR environment using 2 hand-held Vive controllers. Surveys assessing depressed mood and anxiety were presented at the start of the paradigm and additional surveys assessing subjective craving and scene relevance were presented between scenes within the headset. A VAS survey was chosen as the in-task measurement […]
These pieces of evidence suggest that ABCB1 may be a gene of interest for further study
Historically, molecular genetic research on AAB has been limited to the examination of a small number of candidate genes with purported biological relevance; only recently have researchers begun to conduct atheoretical genome-wide scans for this phenotype.13,15,16 In our genome-wide investigation, we found that autosomal SNPs accounted for ~ 25% of the variation in a dimensional […]
Primary trial findings and full study procedures were previously published
These findings occur in the context of extreme poverty and account for simultaneous influences of previous recent violent victimization and amphetamine use. Given the consistency of the relationship between dissociation and physical violence over time, identifying individuals who have high levels of dissociation within a broader context of trauma-informed care for homeless and unstably housed […]
A final note about interpreting the study’s findings is warranted
A reverse pattern appeared for transgender adolescents of color, however, such that transgender Latinx, American Indian or Alaskan Native, Black, Native Hawaiian or Pacific Islander, and multiracial adolescents evidenced greater adjusted odds of more frequent vaping relative to transgender white adolescents. For adolescents unsure of their gender identity, patterns were less consistent. Whereas Latinx, Black, […]
Over time one would expect these factors to further contribute to the effectiveness of CBIs
Use of a theoretical framework helps to explain the mechanisms of change by informing the causal pathways between specific intervention components and behavioral outcomes. Understanding these mechanisms improves our understanding of how and why a particular intervention works. There has been little attention as to how theoretical frameworks have informed the development of CBIs focused […]
Quantitative PCR analysis confirmed N. brasiliensis expression of both of these predicted genes
We validated the bioinformatic predictions for N. brasiliensis by quantitative real-time PCR and mass spectrometry and showed that N. brasiliensis produces endocannabinoids at all life cycle stages. Taken together, these studies show for the first time the production of endocannabinoids by parasitic helminths and suggest that helminth infection-induced endocannabinoids functionally influence the host immune response and […]
The PATH Study is an ongoing household cohort study of tobacco use and health among US youth and adults
One SNP on chromosome 7 in the gene IMMPL2 reached genome-wide significance. Another gene IINHBA-AS1 on chromosome 7 achieved genome-wide significance when analyzed by KGG4 that relies on a composite association score including all SNPs in each known gene. The significance of these associations was not influenced by “p-hacking” statistical biases common in GWAS because […]
College students often drink alcohol and use drugs simultaneously during parties and other social events
The portal content is flexible to allow for real-time tailoring to prevent/reduce misuse, addressing heterogeneity in motives and other risk factors . Use of the fully-crossed 4-group RCT design will help identify the optimal combination of interventions based on risk severity in terms of efficacy, cost-effectiveness, and reimbursement mechanisms. Our conceptual model, which guides the examination […]
The modulation of LPS-regulated gene expression by CBD was more pronounced as compared with THC
Interestingly, the mechanisms that give rise to either the protective or the damaging microglial phenotypes are not fully elucidated. Enhancing the microglial-mediated innate immunity in the CNS and/or preventing the harmful effects associated with their chronic activation may offer new therapeutic approaches for the treatment of brain injury and neurodegenerative diseases. One of the most […]