Informed consent was obtained before starting the behavioral survey, which was administered via hand-held tablet computers. All study procedures were approved by the Institutional Review Board at the University of California, San Francisco. Written consent was obtained from all youths aged 18 years or older and written assent was given by younger participants . Psychosocial […]
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We dichotomized the severity of substance use as low versus moderate to high risk
Regardless, our analyses demonstrate some measure of construct validity in that higher scores on both measures were linked to reporting mental health conditions in our study. Our measure of sexual orientation “outness” was only asked for gay-identified participants, and a general measure should be included in future studies. A nurse-administered structured interview was used to […]
Studies applying CHR criteria to date have focused primarily on psychosis spectrum outcomes
VCAM-1 and ICAM-1 are released in response to inflammation and facilitate the adhesion and migration of immune and viral factors into and across the vascular endothelium . While VCAM-1 is exclusively expressed on endothelial cells, ICAM-1 is also expressed on leukocytes, astrocytes, and microglial cells . uPAR is a glycoprotein expressed on endothelial cells, in addition […]
Our study demonstrated that HIV self-testing can reach individuals at high risk
Risk behavior, attitudes toward HIV testing and treatment, perception of HIV-related stigma, and medical mistrust were not associated with ordering a self-test kit. Finally, we recorded high prevalence of alcohol and cannabis use among participants. Overall, information search sites performed poorly in recruiting and enrolling individuals. The site advertisement metrics showed a better click-through rate […]
The patient’s performance on memory tests and his full scale IQ were rated average
The patient bent down on his right knee and grabbed the dog with his left arm as he held himself up with his right hand, which was in the puddle. He reported a ‘‘buzzing feeling” traveling up his right arm. After bringing his dog to safety, the patient returned to the site, got down on […]
The SCID was used to rule out psychosis and to identify DSM-IV Axis I or cluster A disorders
HCV-infected women were older than HIV-monoinfected women, and both groups were older than women with neither infection. More than half of all women were African American, with the largest proportion among the HCV-infected group. Compared with HIV-infected women and those with neither infection, HCV-infected women were more likely to report being in menopause, having a […]
AEA also blocks the standing-outward K+ current IKso and induces depolarization in cerebellar granule neurons
The changes in A-type potassium channel gating caused by 2-AG include a shift of the voltage-dependent activation of IA in the depolarizing direction, acceleration of the inactivation kinetics, and reduction of the maximal current for large depolarizations. The IA–inhibiting effect of 2-AG likely results from a direct action on the channel through a membrane lipid […]
Subjective memory complaints were also associated with worse verbal memory
One debate in the HIV literature is the extent to which HIV disease is associated with accelerated aging as opposed to other comorbid conditions or other lifestyle factors associated with HIV. However, it is difficult to differentiate the effect of HIV itself versus the downstream effects of HIV or lifestyle factors associated with risk of contracting […]
Life expectancy for persons living with HIV is now similar to the general population
Given the aforementioned paucity of research in the current literature addressing the contribution of genetic and neurocognitive factors on sexual risk behavior, the primary aim of this study was to examine the main effects of executive functioning as well as the main effects of the COMT Val.Met polymorphism on sexual risk behavior among a ethnically […]
Anxiety disorders and substance use disorders are highly prevalent and frequently cooccur
A “pharmacy data only” model included utilization variables related to medications and opioid use data, similar to what might be available to a pharmacy benefit manager researcher. The CHAID procedure identified a number of significant interactions that met the criteria outlined in the Methods section. These interactions were added to the core variables for each […]