Recently, peripheral blood monocyte expression of CCR2 has been shown to predict HAND in combination ART – era HIV cohorts. Elevated levels of CCL2 expression have also been observed in non HIV-positive samples. In patients with mild cognitive impairment and Alzheimer’s disease, higher levels of CSF CCL2 correlated with lower cognitive scores. The presence of elevated […]
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A funnel plot from the six studies did not indicate any major publication bias
One study was excluded from the depression meta-analysis because it assessed aggregate data on crashes, crash deaths, and depression. Effect estimates showed some heterogeneity , hence a random effects model was used. A funnel plot from the six studies did not indicate any major publication bias. Pooled data from the six studies indicate that depression […]
Several studies have shown that PPAR-a activation enhances antioxidative enzyme activities
Thereby it was suggested that increases of brain FAE levels serve a neuroprotective function mediated by CB1-receptors. Oleoylethanolamide does not bind to cannabinoid CBreceptors but to PPAR-a, thereby activating a different neuroprotective mechanism. Sleep deprivation has been hypothesized to represent an oxidative challenge for the brain and that sleep may have a protective role against […]
Prompt linkage to HIV primary care services was provided for all clients
In the context of adolescent health disparities prevention, this approach may be especially useful for identifying and/or implementing asset-based and youth-led interventions.For example, researchers could directly partner with teachers, service providers, parents, and transgender adolescents of color to gather insights based on survey data and in-depth interviews or focus groups into the individual, interpersonal, and […]
One contributor to higher ARB rates in women may be their higher BACs per drink
HOPE HOME staff collected data on alcohol use, drug use, and depression using validated scales in their 6-month followup visits. We used the closest score to our neurologic assessment and excluded individuals with assessments more than 4 weeks after our neurologic exam. The HOPE HOME staff used the Alcohol Use Disorders Identification Test to assess for alcohol use […]
The marijuana tax revenue makes spending increases more palatable to legislators
According to the census, more than one-fifth of state residents were Hispanic or Latino/a in 2015. Colorado’s population growth of nearly eight percent since 2010 ranks third behind only Texas and North Dakota. Politically, Colorado has been trending blue over the past several election cycles. Some have identified the migration of Californians into Colorado as […]
Candidate gene studies have been most effective at identifying human genetic influences on the micro-biome
Using gene array analysis, we have observed that the relative levels of CB1, CB2, GPR18 and TRPV2 as well as of the fatty acid amide hydrolase gene transcripts were not significantly affected by the cannabinoid treatments and their levels did not exceed the 2-fold induction or 50% reduction by either CBD or THC treatment. On the […]
Some population-level studies on patients have been able to confirm this hypothesis
As a result, a young child treated with amphetamines would not necessarily have an increased risk for abuse of other stimulants by the time he or she reached adolescence – when illicit drugs are more readily found. In contrast, if the onset of treatment were to start in the early teens , drug-seeking behavior would […]
Panel illustrate the estimated event study models for EITCs
Our study of social network effects confirms that adults with SUD and MDD will likely benefit from efforts to restructure their social networks by increasing the number of abstinent/non-using supports and decreasing the number of contacts who use substances regularly. Results also suggested that both regular maintenance of positive social networks and avoiding momentary shifts that increase the density […]
Mediators are third variables that statistically explain an association between a predictor and outcome
These studies also suggest that measures of exceptionally poor performance are perhaps better indicators of impairment than continuous performance scores or dichotomous classifications of samples based on arbitrary cutpoints. Despite evidence that patients with psychiatric comorbidity comprise the majority of patients in clinical settings and have greater neurocognitive deficits than patients with substance dependence only previous studies […]