Elimination occurs via first-order kinetics with a half-life of 5-20 hours; however, this can be prolonged up to 30 hours with toxicity.At toxic levels, VPA can cause central nervous system depression, respiratory depression, acute kidney injury, anion-gap metabolic acidosis, and electrolyte abnormalities . VPA is also associated with hepatotoxicity, pancreatitis, hyperammonemic encephalopathy, cerebral edema, and blood […]