In contrast to the 36-year-old waiver policy that preceded it, GBR guarantees a hospital’s annual revenue by calculating global budget based on market share. Adjustments in global budgets are tied to changes in market share and the state’s gross domestic product. In some ways, GBR is an extension of TPR. However, GBR is not a […]
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Recreational use has no demonstrated inherent health benefit
Although we suspect that reducing the number of required questions would free nurses to spend more time on direct patient care and improve efficiency of ED throughput, additional research will be required to study this hypothesis. Studies evaluating ED screening questions often praise their ability to detect at-risk groups without looking at patient oriented outcomes or […]
African Americans accounted for about half of all drug incarcerations
This is partly due to the fact that poorer neighborhoods lack the social capital needed to resist open-air drug markets. But it also reflects the deleterious effects of our mandatory minimum sentencing policies, discussed below. Finally, drug problems are distributed over time. Musto argues that drug epidemics are dampened by a generational learning process in which […]
The current generation of young people faces the worst labour market prospects in decades
This large survey of COVID-19 testing experience among cohorts that follow people living with HIV and people who use drugs across North America provides a snapshot of how the COVID-19 pandemic in its first year may have impacted those who live on the margins of society. This sample included those among the most socially vulnerable […]
The composition of fentanyl analogs has also changed and become more complex over time
The only fentanyl analog detected in 2015 was acetyl fentanyl, which is more potent than heroin, but less potent than fentanyl. Eight new analogs appeared in 2016,12 six more appeared in 2017,13 and seven new analogs appeared in 2018.14 Other non-fentanyl synthetic opioids emerged as well: U-47700 in 2016 and U-48800, U-49900, and U-51754 in […]
The prefrontal cortex is one of the last brain regions to complete its maturation
The brain of an adolescent, much like teenage behavior, undergoes significant developmental changes. This neurodevelopment continues after adolescence, typically until around age 25.The maturational processes in the brain occur in stages, with more basic functions maturing first and areas such as the lateral temporal and frontal lobes, which are responsible for higher cognitive function , developing […]
Conditioned gaping in rats appears to be a selective index of conditioned nausea
A Canadian trans woman working at a grocery store described the need to advocate for herself in response to negative encounters in the washroom: “There have been a few times when we’ve had new people come into the store, new employees, and they’ve had a problem with me using the woman’s washroom. That is just […]
This literature for the domains discussed in this manuscript is too voluminous for a single review
Acquired and hereditaryperipheral neuropathies are associated with increased functional connectivity of the left precuneus/posterior cingulate cortex in the default mode network. This increased connectivity in the default mode network is correlated with duration of peripheral neuropathy and severity of clinical total neuropathy score. As discussed in the introduction, if used in combination, biomarkers related to pain […]
Subjects will provide ratings of their alcohol craving following each cue block
Medication will be stopped based on pre-specified criteria for discontinuation of study medication: development of agitation, hostility, depressed mood, or changes in behavior or thinking not typical of alcohol use or withdrawal severe nausea and vomiting; have a systolic blood pressure greater than 160, or a diastolic blood pressure greater than 100 , or a heart rate greater […]
This pattern of expression in the three subfields of the cornu ammonis was very similar
To reveal the site of synthesis of the endocannabinoid 2-AG in the human hippocampus by determining the localization of its predominant synthesizing enzyme DGL-α , we first sought to identify an antibody with unequivocal specificity for this transmembrane serine hydrolase. Therefore, DGL-α- immunostaining was performed and compared in hippocampal sections derived from wildtype or DGL-α knockout mice. Using […]